| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Ligand | BDBM50367964 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_75908 (CHEMBL686428) |
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| IC50 | 1000±n/a nM |
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| Citation |  LaMattina, JL; McCarthy, PA; Reiter, LA; Holt, WF; Yeh, LA Antiulcer agents. 4-substituted 2-guanidinothiazoles: reversible, competitive, and selective inhibitors of gastric H+,K(+)-ATPase. J Med Chem33:543-52 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Name: | Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Synonyms: | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1/beta chain |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 71495 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Potassium-transporting ATPase alpha chain 1 |
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| Synonyms: | ATP4A | ATP4A_HUMAN | Gastric H(+)/K(+) ATPase subunit alpha | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump |
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| Type: | PROTEIN |
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| Mol. Mass.: | 114109.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_82 |
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| Residue: | 1035 |
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| Sequence: | MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVA
ELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAA
ICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQA
TVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSP
ECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIE
HFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAK
RLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQ
TFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMG
YRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELP
LDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLV
SMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLR
VPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLG
AIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIF
DNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAES
DIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQ
WEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGF
FRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLG
VRCCPGSWWDQELYY
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| Component 2 |
| Name: | Potassium-transporting ATPase subunit beta |
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| Synonyms: | ATP4B | ATP4B_HUMAN | Gastric H(+)/K(+) ATPase subunit beta | Potassium-transporting ATPase | Potassium-transporting ATPase subunit beta | Proton pump beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33369.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_10719 |
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| Residue: | 291 |
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| Sequence: | MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
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| BDBM50367964 |
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| n/a |
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| Name | BDBM50367964 |
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| Synonyms: | CHEMBL1203512 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13N5S |
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| Mol. Mass. | 235.309 |
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| SMILES | Cc1[nH]ccc1-c1nc(N=C(N)N)sc1C |(1.49,-2.06,;.77,-1.06,;1.25,.4,;,1.31,;-1.25,.4,;-.77,-1.06,;-1.68,-2.31,;-1.07,-3.71,;-2.24,-4.71,;-2.12,-6.24,;-3.4,-7.11,;-3.3,-8.34,;-4.51,-6.58,;-3.55,-3.9,;-3.19,-2.41,;-3.99,-1.46,)| |
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| Structure | 
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