Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M3

Ligand

BDBM50452855

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_138851

0.650000±n/a nM

Citation

Cereda, E; Ezhaya, A; Gil Quintero, M; Bellora, E; Dubini, E; Micheletti, R; Schiavone, A; Brambilla, A; Schiavi, GB; Donetti, A Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads. J Med Chem33:2108-13 (1990) [PubMed]

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M3

Name:

Muscarinic acetylcholine receptor M3

Synonyms:

ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3

Type:

Enzyme Catalytic Domain

Mol. Mass.:

66086.66

Organism:

RAT

Description:

Cholinergic, muscarinic M3 CHRM3 RAT::P08483

Residue:

589

Sequence:

MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVK
RSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQ
KDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL

BDBM50452855

n/a

Name

BDBM50452855

Synonyms:

Isoptpo Hyoscine | Scopolamine

Type

Small organic molecule

Emp. Form.

C17H21NO4

Mol. Mass.

303.3529

SMILES

[H][C@@]12O[C@@]1([H])[C@]1([H])C[C@@H](C[C@@]2([H])N1C)OC(=O)[C@H](CO)c1ccccc1 |r,TLB:14:8:12:1.3,2:1:12:8.7.9,2:3:12:8.7.9|

Structure