Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50013848 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_149141 |
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Ki | 4±n/a nM |
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Citation | Galzi, JL; Mejean, A; Ilien, B; Mollereau, C; Meunier, JC; Goeldner, M; Hirth, C Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor. J Med Chem33:2456-64 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50013848 |
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n/a |
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Name | BDBM50013848 |
Synonyms: | 8-[1-(4-Chloro-phenyl)-ethyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | CHEMBL312281 |
Type | Small organic molecule |
Emp. Form. | C21H24ClN3O |
Mol. Mass. | 369.888 |
SMILES | CC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(Cl)cc1 |
Structure |
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