| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Ligand | BDBM50011208 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_80653 |
|---|
| IC50 | 9.4±n/a nM |
|---|
| Citation |  Roth, BD; Bocan, TM; Blankley, CJ; Chucholowski, AW; Creger, PL; Creswell, MW; Ferguson, E; Newton, RS; O'Brien, P; Picard, JA Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase. J Med Chem34:463-6 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Synonyms: | HMDH_RAT | HMG-CoA reductase | Hmgcr |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 96689.85 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Isolated rat liver microsomes were used as enzyme source. |
|---|
| Residue: | 887 |
|---|
| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQSKVSLGLAEDVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
PKKAQDNCCRREPLLVRRNQKLSSVEEDPGVNQDRKVEVIKPLVAEAETSGRATFVLGAS
AASPPLALGAQEPGIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSAKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMSRGPVVRLPRACD
SAEVKSWLETPEGFAVVKEAFDSTSRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMIS
KGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVL
KTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLM
EASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARI
VCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA
|
|
|
|---|
| BDBM50011208 |
|---|
| n/a |
|---|
| Name | BDBM50011208 |
|---|
| Synonyms: | 7-[4-(4-Fluoro-phenyl)-2-isopropyl-6-methyl-1-oxy-pyridin-3-yl]-3,5-dihydroxy-hept-6-enoic acid anion | CHEMBL2368088 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25FNNaO5 |
|---|
| Mol. Mass. | 425.4258 |
|---|
| SMILES | [Na+].CC(C)c1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(cc(C)[n+]1[O-])-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
