Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Aldo-keto reductase family 1 member B1 |
---|
Ligand | BDBM50009777 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_32093 (CHEMBL644296) |
---|
IC50 | 28±n/a nM |
---|
Citation | Mylari, BL; Beyer, TA; Siegel, TW A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. J Med Chem34:1011-8 (1991) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Aldo-keto reductase family 1 member B1 |
---|
Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
Type: | PROTEIN |
Mol. Mass.: | 35797.87 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1512484 |
Residue: | 316 |
Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
|
|
|
BDBM50009777 |
---|
n/a |
---|
Name | BDBM50009777 |
Synonyms: | (ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid | CHEMBL7679 | Ponalrestat | Ponalrestat (statil) | [3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid | [3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid(ponalrestat) |
Type | Small organic molecule |
Emp. Form. | C17H12BrFN2O3 |
Mol. Mass. | 391.191 |
SMILES | OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c2ccccc12 |
Structure |
|