Reaction Details |
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Target | Thromboxane-A synthase |
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Ligand | BDBM50045954 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_213089 |
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IC50 | 400±n/a nM |
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Citation | Cozzi, P; Carganico, G; Fusar, D; Grossoni, M; Menichincheri, M; Pinciroli, V; Tonani, R; Vaghi, F; Salvati, P Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition. J Med Chem36:2964-72 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane-A synthase |
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Name: | Thromboxane-A synthase |
Synonyms: | Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1 |
Type: | PROTEIN |
Mol. Mass.: | 59971.80 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_209768 |
Residue: | 533 |
Sequence: | MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR
QGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLI
ADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQR
CYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLA
RILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMV
TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH
PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV
LGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCL
GVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
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BDBM50045954 |
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n/a |
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Name | BDBM50045954 |
Synonyms: | 4-(3-Imidazol-1-yl-phenyl)-2-methoxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester | CHEMBL103348 |
Type | Small organic molecule |
Emp. Form. | C22H25N3O5 |
Mol. Mass. | 411.451 |
SMILES | CCOC(=O)C1=C(COC)N=C(C)C(C1c1cccc(c1)-n1ccnc1)C(=O)OC |c:5,t:10| |
Structure |
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