| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM50043481 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_47960 (CHEMBL656248) |
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| IC50 | 3.5±n/a nM |
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| Citation |  Bock, MG; DiPardo, RM; Evans, BE; Rittle, KE; Whitter, WL; Garsky, VM; Gilbert, KF; Leighton, JL; Carson, KL; Mellin, EC Development of 1,4-benzodiazepine cholecystokinin type B antagonists. J Med Chem36:4276-92 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin/cholecystokinin type B receptor |
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| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48445.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
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| Residue: | 447 |
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| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM50043481 |
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| n/a |
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| Name | BDBM50043481 |
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| Synonyms: | 1-{1-[2-(4-Methyl-piperazin-1-yl)-2-oxo-ethyl]-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl}-3-m-tolyl-urea; hydrochloride | CHEMBL542967 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32N6O3 |
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| Mol. Mass. | 524.6135 |
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| SMILES | CN1CCN(CC1)C(=O)CN1c2ccccc2C(=NC(NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1 |c:19| |
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| Structure | 
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