| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
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| Ligand | BDBM50046813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_64347 (CHEMBL676078) |
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| IC50 | 750±n/a nM |
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| Citation |  Shiosaki, K; Tasker, AS; Sullivan, GM; Sorensen, BK; von Geldern, TW; Wu-Wong, JR; Marselle, CA; Opgenorth, TJ Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung. J Med Chem36:468-78 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-converting enzyme 1 |
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| Name: | Endothelin-converting enzyme 1 |
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| Synonyms: | ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE) |
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| Type: | Protein |
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| Mol. Mass.: | 86126.89 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P42893 |
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| Residue: | 762 |
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| Sequence: | MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKR
LVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSY
ACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNE
TRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNS
NSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQIL
DFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIV
VYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTC
LPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDED
TRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQ
LRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHE
LTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGEN
IADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLI
TDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
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| BDBM50046813 |
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| n/a |
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| Name | BDBM50046813 |
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| Synonyms: | 4-[2-(2-tert-Butoxycarbonylamino-3,3-dimethyl-butyrylamino)-3-methyl-pentanoylamino]-3-hydroxy-6-methyl-heptanoic acid | CHEMBL343681 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H47N3O7 |
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| Mol. Mass. | 501.6566 |
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| SMILES | CCC(C)C(NC(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C(=O)NC(CC(C)C)C(O)CC(O)=O |
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| Structure | 
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