| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
|---|
| Ligand | BDBM50046842 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_64347 (CHEMBL676078) |
|---|
| IC50 | 13±n/a nM |
|---|
| Citation |  Shiosaki, K; Tasker, AS; Sullivan, GM; Sorensen, BK; von Geldern, TW; Wu-Wong, JR; Marselle, CA; Opgenorth, TJ Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung. J Med Chem36:468-78 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-converting enzyme 1 |
|---|
| Name: | Endothelin-converting enzyme 1 |
|---|
| Synonyms: | ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 86126.89 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P42893 |
|---|
| Residue: | 762 |
|---|
| Sequence: | MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKR
LVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSY
ACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNE
TRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNS
NSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQIL
DFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIV
VYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTC
LPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDED
TRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQ
LRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHE
LTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGEN
IADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLI
TDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
|
|
|
|---|
| BDBM50046842 |
|---|
| n/a |
|---|
| Name | BDBM50046842 |
|---|
| Synonyms: | 3-{4-[2-(2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-methyl-pentanoylamino]-3-hydroxy-6-methyl-heptanoylamino}-propionic acid ethyl ester | CHEMBL141544 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H56N4O8 |
|---|
| Mol. Mass. | 600.7876 |
|---|
| SMILES | CCOC(=O)CCNC(=O)CC(O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)CC)C(C)CC |
|---|
| Structure | 
|
|---|
Search and Browse
