| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
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| Ligand | BDBM50046841 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_64347 (CHEMBL676078) |
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| IC50 | 2.1±n/a nM |
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| Citation |  Shiosaki, K; Tasker, AS; Sullivan, GM; Sorensen, BK; von Geldern, TW; Wu-Wong, JR; Marselle, CA; Opgenorth, TJ Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung. J Med Chem36:468-78 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-converting enzyme 1 |
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| Name: | Endothelin-converting enzyme 1 |
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| Synonyms: | ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE) |
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| Type: | Protein |
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| Mol. Mass.: | 86126.89 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P42893 |
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| Residue: | 762 |
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| Sequence: | MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKR
LVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSY
ACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNE
TRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNS
NSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQIL
DFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIV
VYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTC
LPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDED
TRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQ
LRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHE
LTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGEN
IADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLI
TDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
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| BDBM50046841 |
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| n/a |
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| Name | BDBM50046841 |
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| Synonyms: | CHEMBL357864 | Morpholine-4-carboxylic acid {2-cyclohexyl-1-[1-(2,3-dihydroxy-5-methyl-1-naphthalen-2-ylmethyl-hexylcarbamoyl)-2-methyl-butylcarbamoyl]-ethyl}-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C38H58N4O6 |
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| Mol. Mass. | 666.8903 |
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| SMILES | CCC(C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)[C@@H](O)[C@@H](O)CC(C)C |
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| Structure | 
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