Reaction Details |
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Target | 5-hydroxytryptamine receptor 3A/3B |
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Ligand | BDBM50005836 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_3178 (CHEMBL617706) |
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IC50 | 900±n/a nM |
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Citation | Monge, A; Peña, MC; Palop, JA; Calderó, JM; Roca, J; García, E; Romero, G; del Río, J; Lasheras, B Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. J Med Chem37:1320-5 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 3A/3B |
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Name: | 5-hydroxytryptamine receptor 3A/3B |
Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 2974 |
Components: | This complex has 2 components. |
Component 1 |
Name: | 5-hydroxytryptamine receptor 3B |
Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor |
Type: | PROTEIN |
Mol. Mass.: | 50328.78 |
Organism: | Rattus norvegicus |
Description: | EBI_11885 |
Residue: | 437 |
Sequence: | MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLC
VHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFV
DVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDID
LGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVV
SLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGV
FFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTE
SPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVL
GLYTVTLCSLWALWSRM
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Component 2 |
Name: | 5-hydroxytryptamine receptor 3A |
Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 55428.70 |
Organism: | RAT |
Description: | 5-HT3 HTR3A RAT::P35563 |
Residue: | 483 |
Sequence: | MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS
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BDBM50005836 |
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n/a |
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Name | BDBM50005836 |
Synonyms: | 4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide | 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide | CHEMBL560739 | CISAPRIDE | PROPULSID | US10167299, Cisapride | US10800776, Example Cisapride | US9221790, Cisapride | cid_5311047 |
Type | Small organic molecule |
Emp. Form. | C23H29ClFN3O4 |
Mol. Mass. | 465.945 |
SMILES | COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC |
Structure |
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