Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50035107 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_202043 (CHEMBL809516) |
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IC50 | 14±n/a nM |
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Citation | Perregaard, J; Moltzen, EK; Meier, E; Sánchez, C Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem38:1998-2008 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25266.54 |
Organism: | RAT |
Description: | Q9R0C9 |
Residue: | 223 |
Sequence: | MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRY
WAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
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BDBM50035107 |
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n/a |
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Name | BDBM50035107 |
Synonyms: | 1'-{4-[1-(1,3-thiazol-2-yl)-1H-3-indolyl]butyl}spiro[1,3-dihydroisobenzofuran-1,4'-(hexahydropyridine)] | CHEMBL59306 |
Type | Small organic molecule |
Emp. Form. | C27H29N3OS |
Mol. Mass. | 443.604 |
SMILES | C(CCc1cn(-c2nccs2)c2ccccc12)CN1CCC2(CC1)OCc1ccccc21 |
Structure |
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