| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50031296 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_83767 (CHEMBL693825) |
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| IC50 | 44±n/a nM |
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| Citation |  Abou-Gharbia, M; Moyer, JA; Nielsen, ST; Webb, M; Patel, U New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists. J Med Chem38:4026-32 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50031296 |
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| n/a |
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| Name | BDBM50031296 |
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| Synonyms: | 7-[3-(4-Benzhydryl-piperidin-1-yl)-propyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; compound with (E)-but-2-enedioic acid | CHEMBL338611 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33N5O2 |
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| Mol. Mass. | 471.5939 |
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| SMILES | Cn1c2ncn(CCCN3CCC(CC3)C(c3ccccc3)c3ccccc3)c2c(=O)n(C)c1=O |
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| Structure | 
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