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Target5-hydroxytryptamine receptor 3A/3B
LigandBDBM50060274
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2997 (CHEMBL872925)
Ki 3±n/a nM
Citation Heidempergher, FPillan, APinciroli, VVaghi, FArrigoni, CBolis, GCaccia, CDho, LMcArthur, RVarasi, M Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding. J Med Chem40:3369-80 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 3A/3B
Name:5-hydroxytryptamine receptor 3A/3B
Synonyms:Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 2974
Components:This complex has 2 components.
Component 1
Name:5-hydroxytryptamine receptor 3B
Synonyms:5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor
Type:PROTEIN
Mol. Mass.:50328.78
Organism:Rattus norvegicus
Description:EBI_11885
Residue:437
Sequence:
MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLC
VHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFV
DVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDID
LGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVV
SLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGV
FFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTE
SPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVL
GLYTVTLCSLWALWSRM
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Component 2
Name:5-hydroxytryptamine receptor 3A
Synonyms:5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R
Type:Enzyme Catalytic Domain
Mol. Mass.:55428.70
Organism:RAT
Description:5-HT3 HTR3A RAT::P35563
Residue:483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS
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BDBM50060274
n/a
NameBDBM50060274
Synonyms:1-(1-Aza-bicyclo[2.2.2]oct-3-yl)-3-(3-bromo-phenyl)-imidazolidin-2-one | CHEMBL333144
TypeSmall organic molecule
Emp. Form.C16H20BrN3O
Mol. Mass.350.254
SMILESBrc1cccc(c1)N1CCN(C2CN3CCC2CC3)C1=O |TLB:10:11:15.14:17.18,(7,-9.48,;8.35,-10.25,;8.35,-11.79,;9.67,-12.56,;11.02,-11.79,;11.02,-10.25,;9.67,-9.48,;12.33,-9.44,;13.74,-10.08,;14.77,-8.93,;14,-7.58,;14.61,-6.17,;14.83,-4.76,;16.08,-3.38,;17.88,-3.6,;17.59,-4.98,;15.76,-4.73,;15.22,-3.48,;15.64,-2.38,;12.49,-7.94,;11.34,-6.91,)|
Structure
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