Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Phenylethanolamine N-methyltransferase |
---|
Ligand | BDBM50072975 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_152397 (CHEMBL764113) |
---|
Ki | 45000±n/a nM |
---|
Citation | Grunewald, GL; Dahanukar, VH; Jalluri, RK; Criscione, KR Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor. J Med Chem42:118-34 (1999) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Phenylethanolamine N-methyltransferase |
---|
Name: | Phenylethanolamine N-methyltransferase |
Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
Type: | Enzyme |
Mol. Mass.: | 30916.97 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 283 |
Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
|
|
|
BDBM50072975 |
---|
n/a |
---|
Name | BDBM50072975 |
Synonyms: | 7-Methanesulfinyl-1,2,3,4-tetrahydro-isoquinoline | CHEMBL27954 |
Type | Small organic molecule |
Emp. Form. | C10H13NOS |
Mol. Mass. | 195.281 |
SMILES | CS(=O)c1ccc2CCNCc2c1 |
Structure |
|