| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 4 |
|---|
| Ligand | BDBM50079303 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_3259 (CHEMBL617869) |
|---|
| IC50 | >1000±n/a nM |
|---|
| Citation |  Tapia, I; Alonso-Cires, L; López-Tudanca, PL; Mosquera, R; Labeaga, L; Innerárity, A; Orjales, A 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives. J Med Chem42:2870-80 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 4 |
|---|
| Name: | 5-hydroxytryptamine receptor 4 |
|---|
| Synonyms: | 5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43735.29 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | 5-HT4 HTR4 GUINEA PIG::O70528 |
|---|
| Residue: | 388 |
|---|
| Sequence: | MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
|
|
|
|---|
| BDBM50079303 |
|---|
| n/a |
|---|
| Name | BDBM50079303 |
|---|
| Synonyms: | 3-Isopropyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid [2-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-ethyl]-amide | CHEMBL328641 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H31N5O4 |
|---|
| Mol. Mass. | 465.5447 |
|---|
| SMILES | CC(C)n1c2ccccc2n(C(=O)NCCN2CCN(Cc3ccc4OCOc4c3)CC2)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
