| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(2) dopamine receptor |
|---|
| Ligand | BDBM50083339 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_60058 (CHEMBL671372) |
|---|
| Ki | 698±n/a nM |
|---|
| Citation |  Belliotti, TR; Wustrow, DJ; Brink, WA; Zoski, KT; Shih, YH; Whetzel, SZ; Georgic, LM; Corbin, AE; Akunne, HC; Heffner, TG; Pugsley, TA; Wise, LD A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent. J Med Chem42:5181-7 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(2) dopamine receptor |
|---|
| Name: | D(2) dopamine receptor |
|---|
| Synonyms: | D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 |
|---|
| Type: | Cell-surface receptors |
|---|
| Mol. Mass.: | 50647.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14416 |
|---|
| Residue: | 443 |
|---|
| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
|
|
|
|---|
| BDBM50083339 |
|---|
| n/a |
|---|
| Name | BDBM50083339 |
|---|
| Synonyms: | 6-[4-(4-Methoxy-phenyl)-piperidin-1-ylmethyl]-4H-benzo[1,4]oxazin-3-one | CHEMBL146757 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24N2O3 |
|---|
| Mol. Mass. | 352.4269 |
|---|
| SMILES | COc1ccc(cc1)C1CCN(Cc2ccc3OCC(=O)Nc3c2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
