| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M5 |
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| Ligand | BDBM50083342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_139394 (CHEMBL747160) |
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| Ki | 964±n/a nM |
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| Citation |  Belliotti, TR; Wustrow, DJ; Brink, WA; Zoski, KT; Shih, YH; Whetzel, SZ; Georgic, LM; Corbin, AE; Akunne, HC; Heffner, TG; Pugsley, TA; Wise, LD A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent. J Med Chem42:5181-7 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M5 |
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| Name: | Muscarinic acetylcholine receptor M5 |
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| Synonyms: | ACM5_HUMAN | CHRM5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60102.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1517990 |
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| Residue: | 532 |
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| Sequence: | MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
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| BDBM50083342 |
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| n/a |
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| Name | BDBM50083342 |
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| Synonyms: | 7-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-4H-benzo[1,4]oxazin-3-one | CHEMBL346389 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20ClN3O2 |
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| Mol. Mass. | 357.834 |
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| SMILES | Clc1ccc(cc1)N1CCN(Cc2ccc3NC(=O)COc3c2)CC1 |
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| Structure | 
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