Ki Summary

Reaction Details

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Target

Potassium voltage-gated channel subfamily A member 3

Ligand

BDBM50099583

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_214954 (CHEMBL821183)

IC50

86±n/a nM

Citation

Coghlan, MJ; Carroll, WA; Gopalakrishnan, M Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. J Med Chem44:1627-53 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Potassium voltage-gated channel subfamily A member 3

Name:

Potassium voltage-gated channel subfamily A member 3

Synonyms:

Type:

PROTEIN

Mol. Mass.:

63835.47

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1513935

Residue:

575

Sequence:

MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDH
LLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLK
TLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIF
SEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVS
VLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVET
LCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSL
AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE
ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV
SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHS
AFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

BDBM50099583

n/a

Name

BDBM50099583

Synonyms:

5-isopropenyloxy-1b,3a,10b-trimethyl-2,3-di(methylcarbonyloxy)-5a-(1-methylcarbonyloxyethyl)-14-methylene-1a-methyloxycarbonyl-8-oxo-1a,1b,2,3,3a,3b,4,5,5a,6,8,10a,10b,11,12,12a,12b,13,14,14a-icosahydrooxireno[3',2':7,8]chryseno[2,1-c]oxepin-4-ylaceta | CHEMBL290227

Type

Small organic molecule

Emp. Form.

C41H54O14

Mol. Mass.

770.8591

SMILES

COC(=O)[C@@]12O[C@@H]1C(=C)CC1[C@@H]3CC[C@@]4(C)[C@@H]5C=CC(=O)OC[C@]5([C@@H](C)OC(C)=O)[C@@H](OC(C)=C)[C@@H](OC(C)=O)[C@@H]4[C@@]3(C)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]21C |c:18|

Structure