| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
|---|
| Ligand | BDBM50055017 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_145004 (CHEMBL756266) |
|---|
| Ki | 40±n/a nM |
|---|
| Citation |  Houlihan, WJ; Kelly, L; Pankuch, J; Koletar, J; Brand, L; Janowsky, A; Kopajtic, TA Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. J Med Chem45:4097-109 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent noradrenaline transporter |
|---|
| Name: | Sodium-dependent noradrenaline transporter |
|---|
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69337.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23975 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
|
|
|
|---|
| BDBM50055017 |
|---|
| n/a |
|---|
| Name | BDBM50055017 |
|---|
| Synonyms: | 7,8-Dichloro-5-(4-chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol | CHEMBL132955 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H11Cl3N2O |
|---|
| Mol. Mass. | 353.63 |
|---|
| SMILES | OC1(N2CCN=C2c2cc(Cl)c(Cl)cc12)c1ccc(Cl)cc1 |c:5| |
|---|
| Structure | 
|
|---|
Search and Browse
