Ki Summary

Reaction Details

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Target

Somatostatin receptor type 3

Ligand

BDBM50136786

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_200693 (CHEMBL807103)

IC50

6.7±n/a nM

Citation

Erchegyi, J; Penke, B; Simon, L; Michaelson, S; Wenger, S; Waser, B; Cescato, R; Schaer, JC; Reubi, JC; Rivier, J Novel sst(4)-selective somatostatin (SRIF) agonists. 2. Analogues with beta-methyl-3-(2-naphthyl)alanine substitutions at position 8. J Med Chem46:5587-96 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Somatostatin receptor type 3

Name:

Somatostatin receptor type 3

Synonyms:

SOMATOSTATIN SST3 | SS-3-R | SS3-R | SS3R | SSR-28 | SSR3_HUMAN | SSTR3 | Somatostatin receptor type 3 (SSTR3)

Type:

Protein

Mol. Mass.:

45855.97

Organism:

Homo sapiens (Human)

Description:

P32745

Residue:

418

Sequence:

MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLL
GNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVM
AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVV
FSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRV
WAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVA
LPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEE
SREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL

BDBM50136786

n/a

Name

BDBM50136786

Synonyms:

(13S,25S)-25-Amino-13-(4-amino-butyl)-7-((R)-(S)-1-benzyl)-19-(S)-1-benzyl-22-benzyl-10-((S)-1-hydroxy-ethyl)-16-naphthalen-1-ylmethyl-6,9,12,15,24-pentaoxo-18-(S)-oxo-21-(R)-oxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylicacid | CHEMBL410600

Type

Small organic molecule

Emp. Form.

C56H67N9O10S2

Mol. Mass.

1090.315

SMILES

C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O

Structure