| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholinesterase |
|---|
| Ligand | BDBM50064051 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_41427 (CHEMBL654407) |
|---|
| IC50 | 4600±n/a nM |
|---|
| Citation |  Meier, C; Ducho, C; Görbig, U; Esnouf, R; Balzarini, J Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship. J Med Chem47:2839-52 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholinesterase |
|---|
| Name: | Cholinesterase |
|---|
| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
|---|
| Type: | Homotetramer |
|---|
| Mol. Mass.: | 68422.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06276 |
|---|
| Residue: | 602 |
|---|
| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
|
|
|
|---|
| BDBM50064051 |
|---|
| n/a |
|---|
| Name | BDBM50064051 |
|---|
| Synonyms: | 5-Methyl-1-[(2R,5S)-5-(6-methyl-2-oxo-4H-2lambda*5*-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione | 5-Methyl-1-[5-(6-methyl-2-oxo-4H-2lambda*5*-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione | BDBM50206639 | CHEMBL223807 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19N2O7P |
|---|
| Mol. Mass. | 406.3264 |
|---|
| SMILES | Cc1ccc2OP(=O)(OC[C@H]3O[C@H](C=C3)n3cc(C)c(=O)[nH]c3=O)OCc2c1 |r,c:13| |
|---|
| Structure | 
|
|---|
Search and Browse
