Reaction Details | |||
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Target | Interleukin-2 receptor subunit alpha | ||
Ligand | BDBM50148008 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_89084 (CHEMBL878448) | ||
IC50 | 10000±n/a nM | ||
Citation | Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem47:3111-30 (2004) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Interleukin-2 receptor subunit alpha | |||
Name: | Interleukin-2 receptor subunit alpha | ||
Synonyms: | CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 30733.96 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_89085 | ||
Residue: | 268 | ||
Sequence: |
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BDBM50148008 | |||
n/a | |||
Name | BDBM50148008 | ||
Synonyms: | (R)-2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide | 2-(R)-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide | 2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE | CHEMBL106187 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H33Cl2N7O2 | ||
Mol. Mass. | 534.481 | ||
SMILES | NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1cccc(Cl)c1Cl |wD:4.3,(11.97,-.63,;11.27,.74,;12.09,2.04,;9.73,.81,;8.91,-.5,;9.61,-1.87,;11.15,-1.92,;11.85,-3.3,;11.03,-4.59,;9.49,-4.52,;8.78,-3.16,;7.37,-.43,;6.65,.92,;6.54,-1.73,;5,-1.68,;4.18,-2.97,;4.9,-4.34,;2.64,-2.91,;1.82,-4.21,;.29,-4.15,;-.42,-2.78,;.38,-1.48,;1.92,-1.55,;-1.96,-2.71,;-2.91,-3.93,;-4.36,-3.39,;-4.31,-1.87,;-2.82,-1.45,;-5.64,-4.25,;-6.99,-3.48,;-8.32,-4.25,;-8.32,-5.79,;-6.99,-6.56,;-6.99,-8.1,;-5.64,-5.79,;-4.31,-6.56,)| | ||
Structure |