| Reaction Details |
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 | Report a problem with these data |
| Target | Matrilysin |
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| Ligand | BDBM50161327 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305735 (CHEMBL829407) |
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| IC50 | >24300±n/a nM |
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| Citation |  Rossello, A; Nuti, E; Carelli, P; Orlandini, E; Macchia, M; Nencetti, S; Zandomeneghi, M; Balzano, F; Uccello Barretta, G; Albini, A; Benelli, R; Cercignani, G; Murphy, G; Balsamo, A N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP. Bioorg Med Chem Lett15:1321-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrilysin |
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| Name: | Matrilysin |
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| Synonyms: | MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29681.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09237 |
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| Residue: | 267 |
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| Sequence: | MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD
PQNFKLSQDDIKGIQKLYGKRSNSRKK
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| BDBM50161327 |
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| n/a |
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| Name | BDBM50161327 |
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| Synonyms: | CHEMBL362651 | {(R)-3-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-3-hydroxycarbamoyl-propyl}-carbamic acid benzyl ester | {(S)-4-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-4-hydroxycarbamoyl-butyl}-carbamic acid benzyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31N3O7S |
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| Mol. Mass. | 541.616 |
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| SMILES | CC(C)ON([C@H](CCNC(=O)OCc1ccccc1)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1 |
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| Structure | 
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