| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
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| Ligand | BDBM50020883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306676 (CHEMBL830010) |
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| IC50 | 2740±n/a nM |
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| Citation |  Héja, L; Kovács, I; Szárics, E; Incze, M; Temesváriné-Major, E; Dörnyei, G; Peredy-Kajtár, M; Gács-Baitz, E; Szántay, C; Kardos, J Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem47:5620-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 1 |
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| Name: | Sodium- and chloride-dependent GABA transporter 1 |
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| Synonyms: | GABA transporter | Gabt1 | Gat-1 | Gat1 | SC6A1_RAT | Slc6a1 | Solute carrier family 6 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67006.26 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1472611 |
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| Residue: | 599 |
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| Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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| BDBM50020883 |
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| n/a |
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| Name | BDBM50020883 |
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| Synonyms: | (R)-Piperidine-3-carboxylic acid | (R)-nipecotic acid | CHEMBL77575 | Nipecotic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C6H11NO2 |
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| Mol. Mass. | 129.157 |
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| SMILES | OC(=O)[C@@H]1CCCNC1 |r| |
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| Structure | 
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