| Reaction Details |
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 | Report a problem with these data |
| Target | Progesterone receptor |
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| Ligand | BDBM50172045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321436 (CHEMBL880244) |
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| IC50 | 51±n/a nM |
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| Citation |  Betageri, R; Zhang, Y; Zindell, RM; Kuzmich, D; Kirrane, TM; Bentzien, J; Cardozo, M; Capolino, AJ; Fadra, TN; Nelson, RM; Paw, Z; Shih, DT; Shih, CK; Zuvela-Jelaska, L; Nabozny, G; Thomson, DS Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand. Bioorg Med Chem Lett15:4761-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Progesterone receptor |
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| Name: | Progesterone receptor |
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| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
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| Type: | Protein |
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| Mol. Mass.: | 98979.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06401 |
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| Residue: | 933 |
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| Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
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| BDBM50172045 |
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| n/a |
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| Name | BDBM50172045 |
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| Synonyms: | 2-(3,5-Dimethyl-benzyl)-4-(5-fluoro-2-hydroxy-phenyl)-2-hydroxy-4-methyl-pentanoic acid (1-oxo-1,3-dihydro-isobenzofuran-5-yl)-amide | CHEMBL194301 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30FNO5 |
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| Mol. Mass. | 491.5506 |
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| SMILES | Cc1cc(C)cc(CC(O)(CC(C)(C)c2cc(F)ccc2O)C(=O)Nc2ccc3C(=O)OCc3c2)c1 |
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| Structure | 
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