| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase catalytic subunit |
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| Ligand | BDBM50172517 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321600 (CHEMBL872297) |
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| pH | 7.5±n/a |
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| IC50 | >40000±n/a nM |
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| Comments | extracted |
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| Citation |  Schnute, ME; Cudahy, MM; Brideau, RJ; Homa, FL; Hopkins, TA; Knechtel, ML; Oien, NL; Pitts, TW; Poorman, RA; Wathen, MW; Wieber, JL 4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases. J Med Chem48:5794-804 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase catalytic subunit |
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| Name: | DNA polymerase catalytic subunit |
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| Synonyms: | DNA polymerase | DPOL_VZVD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 134062.58 |
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| Organism: | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
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| Description: | ChEMBL_321600 |
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| Residue: | 1194 |
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| Sequence: | MAIRTGFCNPFLTQASGIKYNPRTGRGSNREFLHSYKTTMSSFQFLAPKCLDEDVPMEER
KGVHVGTLSRPPKVYCNGKEVPILDFRCSSPWPRRVNIWGEIDFRGDKFDPRFNTFHVYD
IVETTEAASNGDVSRFATATRPLGTVITLLGMSRCGKRVAVHVYGICQYFYINKAEVDTA
CGIRSGSELSVLLAECLRSSMITQNDATLNGDKNAFHGTSFKSASPESFRVEVIERTDVY
YYDTQPCAFYRVYSPSSKFTNYLCDNFHPELKKYEGRVDATTRFLMDNPGFVSFGWYQLK
PGVDGERVRVRPASRQLTLSDVEIDCMSDNLQAIPNDDSWPDYKLLCFDIECKSGGSNEL
AFPDATHLEDLVIQISCLLYSIPRQSLEHILLFSLGSCDLPQRYVQEMKDAGLPEPTVLE
FDSEFELLIAFMTLVKQYAPEFATGYNIVNFDWAFIMEKLNSIYSLKLDGYGSINRGGLF
KIWDVGKSGFQRRSKVKINGLISLDMYAIATEKLKLSSYKLDSVAREALNESKRDLPYKD
IPGYYASGPNTRGIIGEYCIQDSALVGKLFFKYLPHLELSAVARLARITLTKAIYDGQQV
RIYTCLLGLASSRGFILPDGGYPATFEYKDVIPDVGDVEEEMDEDESVSPTGTSSGRNVG
YKGARVFDPDTGFYIDPVVVLDFASLYPSIIQAHNLCFTTLTLNFETVKRLNPSDYATFT
VGGKRLFFVRSNVRESLLGVLLKDWLAMRKAIRARIPGSSSDEAVLLDKQQAAIKVVCNS
VYGFTGVAQGFLPCLYVAATVTTIGRQMLLSTRDYIHNNWAAFERFITAFPDIESSVLSQ
KAYEVKVIYGDTDSVFIRFKGVSVEGIAKIGEKMAHIISTALFCPPIKLECEKTFIKLLL
ITKKKYIGVIYGGKVLMKGVDLVRKNNCQFINDYARKLVELLLYDDTVSRAAAEASCVSI
AEWNRRAMPSGMAGFGRIIADAHRQITSPKLDINKFVMTAELSRPPSAYINRRLAHLTVY
YKLVMRQGQIPNVRERIPYVIVAPTDEVEADAKSVALLRGDPLQNTAGKRCGEAKRKLII
SDLAEDPIHVTSHGLSLNIDYYFSHLIGTASVTFKALFGNDTKLTERLLKRFIPETRVVN
VKMLNRLQAAGFVCIHAPCWDNKMNTEAEITEEEQSHQIMRRVFCIPKAILHQS
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| BDBM50172517 |
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| n/a |
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| Name | BDBM50172517 |
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| Synonyms: | 4-Hydroxy-6-(3-hydroxy-propyl)-quinoline-3-carboxylic acid 4-chloro-benzylamide | CHEMBL363625 | N-(4-chlorobenzyl)-4-hydroxy-6-(3-hydroxypropyl)quinoline-3-carboxamide | PNU-181465 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19ClN2O3 |
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| Mol. Mass. | 370.829 |
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| SMILES | OCCCc1ccc2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1 |
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| Structure | 
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