Reaction Details |
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Target | Heme oxygenase 2 |
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Ligand | BDBM50044424 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_368936 (CHEMBL869047) |
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IC50 | 28000±n/a nM |
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Citation | Vlahakis, JZ; Kinobe, RT; Bowers, RJ; Brien, JF; Nakatsu, K; Szarek, WA Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J Med Chem49:4437-41 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heme oxygenase 2 |
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Name: | Heme oxygenase 2 |
Synonyms: | HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2 |
Type: | Enzyme |
Mol. Mass.: | 35754.99 |
Organism: | Rattus norvegicus (rat) |
Description: | HO-2 obtained from rat brain was used in enzyme assays. |
Residue: | 315 |
Sequence: | MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGN
IKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENW
EEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTG
EGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAG
SMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILA
ASVALVAGLLAWYYM
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BDBM50044424 |
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n/a |
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Name | BDBM50044424 |
Synonyms: | 4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlorophenethyl)-1,3-dioxolan-4-yl)methylthio)benzenamine | 4-{(2S,4S)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethylsulfanyl}-phenylamine | 4-{2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethylsulfanyl}-phenylamine | Azalanstat dihydrochloride | CHEMBL70611 |
Type | Small organic molecule |
Emp. Form. | C22H24ClN3O2S |
Mol. Mass. | 429.963 |
SMILES | Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1 |
Structure |
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