| Reaction Details |
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 | Report a problem with these data |
| Target | Transporter |
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| Ligand | BDBM50196225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_418047 (CHEMBL911775) |
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| Ki | 983±n/a nM |
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| Citation |  Zou, MF; Cao, J; Kopajtic, T; Desai, RI; Katz, JL; Newman, AH Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. J Med Chem49:6391-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transporter |
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| Name: | Transporter |
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| Synonyms: | Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66787.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1463061 |
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| Residue: | 597 |
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| Sequence: | MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF
YMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLN
LPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI
GLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG
INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTIN
CVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFL
MLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLT
LLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLL
FVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAY
GITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
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| BDBM50196225 |
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| n/a |
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| Name | BDBM50196225 |
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| Synonyms: | CHEMBL217295 | S-(+)-2beta-Hydroxymethyl-3alpha-[bis(4-fluorophenyl)methoxy]-tropane |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25F2NO2 |
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| Mol. Mass. | 373.4362 |
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| SMILES | CN1C2CCC1[C@@H](CO)[C@H](C2)OC(c1ccc(F)cc1)c1ccc(F)cc1 |TLB:7:6:1:3.4,THB:11:9:1:3.4| |
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| Structure | 
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