Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-2 |
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Ligand | BDBM50156759 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_422928 (CHEMBL908196) |
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IC50 | 74300±n/a nM |
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Citation | Kiviranta, PH; Leppänen, J; Kyrylenko, S; Salo, HS; Lahtela-Kakkonen, M; Tervo, AJ; Wittekindt, C; Suuronen, T; Kuusisto, E; Järvinen, T; Salminen, A; Poso, A; Wallén, EA N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors. J Med Chem49:7907-11 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-2 |
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Name: | NAD-dependent protein deacetylase sirtuin-2 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
Type: | Hydrolase |
Mol. Mass.: | 43172.62 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 389 |
Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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BDBM50156759 |
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n/a |
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Name | BDBM50156759 |
Synonyms: | 5-((2-(3,5-dichloro-2-hydroxybenzylideneamino)phenylthio)methyl)-4-(hydroxymethyl)-2-methylpyridin-3-ol | 5-(2-{[1-(3,5-dichloro-2-hydroxyphenyl)meth-(E)-ylidene]amino}phenylsulfanylmethyl-4-hydroxymethyl-2-methylpyridin-3-ol | CHEMBL220458 |
Type | Small organic molecule |
Emp. Form. | C21H18Cl2N2O3S |
Mol. Mass. | 449.35 |
SMILES | Cc1ncc(CSc2ccccc2\N=C\c2cc(Cl)cc(Cl)c2O)c(CO)c1O |
Structure |
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