| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Ligand | BDBM50241187 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_438459 (CHEMBL887559) |
|---|
| IC50 | 80000±n/a nM |
|---|
| Citation |  Kiviranta, PH; Leppänen, J; Rinne, VM; Suuronen, T; Kyrylenko, O; Kyrylenko, S; Kuusisto, E; Tervo, AJ; Järvinen, T; Salminen, A; Poso, A; Wallén, EA N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors. Bioorg Med Chem Lett17:2448-51 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Name: | NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 43172.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 389 |
|---|
| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
|
|
|
|---|
| BDBM50241187 |
|---|
| n/a |
|---|
| Name | BDBM50241187 |
|---|
| Synonyms: | (E)-N-(1-(2-(5-fluoro-1H-indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamide | CHEMBL245011 | N-(1-(2-(5-fluoro-1H-indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24FN3O3 |
|---|
| Mol. Mass. | 409.4534 |
|---|
| SMILES | CC(C)(NC(=O)\C=C\c1ccc(O)cc1)C(=O)NCCc1c[nH]c2ccc(F)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
