Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-2 |
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Ligand | BDBM50241185 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_438459 (CHEMBL887559) |
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IC50 | 50000±n/a nM |
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Citation | Kiviranta, PH; Leppänen, J; Rinne, VM; Suuronen, T; Kyrylenko, O; Kyrylenko, S; Kuusisto, E; Tervo, AJ; Järvinen, T; Salminen, A; Poso, A; Wallén, EA N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors. Bioorg Med Chem Lett17:2448-51 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-2 |
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Name: | NAD-dependent protein deacetylase sirtuin-2 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
Type: | Hydrolase |
Mol. Mass.: | 43172.62 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 389 |
Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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BDBM50241185 |
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n/a |
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Name | BDBM50241185 |
Synonyms: | (E)-N-(1-(2-(1H-indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamide | CHEMBL242867 | N-(1-(2-(1H-indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamide |
Type | Small organic molecule |
Emp. Form. | C23H25N3O3 |
Mol. Mass. | 391.4629 |
SMILES | CC(C)(NC(=O)\C=C\c1ccc(O)cc1)C(=O)NCCc1c[nH]c2ccccc12 |
Structure |
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