| Reaction Details |
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 | Report a problem with these data |
| Target | Nitric oxide synthase, inducible |
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| Ligand | BDBM50206070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_442521 (CHEMBL892686) |
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| IC50 | 44000±n/a nM |
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| Citation |  Patman, J; Bhardwaj, N; Ramnauth, J; Annedi, SC; Renton, P; Maddaford, SP; Rakhit, S; Andrews, JS Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett17:2540-4 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nitric oxide synthase, inducible |
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| Name: | Nitric oxide synthase, inducible |
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| Synonyms: | NOS2_RAT | Nos2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 130642.55 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_976228 |
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| Residue: | 1147 |
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| Sequence: | MACPWKFLFRVKSYQGDLKEEKDINNNVEKTPGAIPSPTTQDDPKSHKHQNGFPQFLTGT
AQNVPESLDKLHVTPSTRPQHVRIKNWGNGEIFHDTLHHKATSDISCKSKLCMGSIMNSK
SLTRGPRDKPTPVEELLPQAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTL
DELIFATKMAWRNAPRCIGRIQWSNLQVFDARSCSTASEMFQHICRHILYATNSGNIRSA
ITVFPQRSDGKHDFRIWNSQLIRYAGYQMPDGTIRGDPATLEFTQLCIDLGWKPRYGRFD
VLPLVLQAHGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLE
FPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINAAVL
HSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNY
VLSPFYYYQIEPWKTHIWQDEKLRPRRREIRFTVLVKAVFFASVLMRKVMASRVRATVLF
ATETGKSEALARDLAALFSYAFNTKVVCMEQYKANTLEEEQLLLVVTSTFGNGDCPSNGQ
TLKKSLFMMKELGHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELS
GQEDAFRSWAVQTFRAACETFDVRSKHCIQIPKRYTSNATWEPEQYKLTQSPESLDLNKA
LSSIHAKNVFTMRLKSLQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTAL
VQGILERVVDCSSPDQTVCLEVLDESGSYWVKDKRLPPCSLRQALTYFLDITTPPTQLQL
HKLARFATEETHRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLRVPAAFLLSQLPIL
KPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWINNLKPEDPVPCFVRS
VSGFQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHRGLKGGRMTLVFGCRHPEEDH
LYQEEMQEMVRKGVLFQVHTGYSRLPGKPKVYVQDILQKELADEVFSVLHGEQGHLYVCG
DVRMARDVATTLKKLVAAKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGNTLE
EPKGTRL
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| BDBM50206070 |
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| n/a |
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| Name | BDBM50206070 |
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| Synonyms: | CHEMBL412797 | N-[2-(2-morpholin-4-yl-ethylamino)-benzothiazol-6-yl]-thiophene-2-carboxamidine |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N5OS2 |
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| Mol. Mass. | 387.522 |
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| SMILES | NC(=Nc1ccc2nc(NCCN3CCOCC3)sc2c1)c1cccs1 |w:2.2| |
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| Structure | 
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