Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M2

Ligand

BDBM50225215

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_451100 (CHEMBL900173)

EC50

0.9±n/a nM

Citation

Elsinghorst, PW; Cieslik, JS; Mohr, K; Tränkle, C; Gütschow, M First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. J Med Chem50:5685-95 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M2

Name:

Muscarinic acetylcholine receptor M2

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

51688.65

Organism:

GUINEA PIG

Description:

Cholinergic, muscarinic 0 GUINEA PIG::P06199

Residue:

466

Sequence:

MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRI
VKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR

BDBM50225215

n/a

Name

BDBM50225215

Synonyms:

N,N,N-triethyl-2-(3-(((6-(2-(1,2,3,4-tetrahydroacridin-9-yl)-hydrazino)-6-oxohexyl)amino)carbonyl)-5-((2-triethylammonio)-ethoxy)phenoxy)ethanammonium dibromide hydrochloride

Type

Small organic molecule

Emp. Form.

C42H66N6O4

Mol. Mass.

719.0101

SMILES

CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(c1)C(=O)NCCCCCC(=O)NNc1c2CCCCc2nc2ccccc12

Structure