Ki Summary

Reaction Details

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Target

Thymidine kinase

Ligand

BDBM50132291

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_454746 (CHEMBL886768)

IC50

24000±n/a nM

Citation

Ciliberti, N; Manfredini, S; Angusti, A; Durini, E; Solaroli, N; Vertuani, S; Buzzoni, L; Bonache, MC; Ben-Shalom, E; Karlsson, A; Saada, A; Balzarini, J Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem15:3065-81 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Thymidine kinase

Name:

Thymidine kinase

Synonyms:

KITH_HHV1 | TK | UL23

Type:

PROTEIN

Mol. Mass.:

40902.47

Organism:

Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1)

Description:

ChEMBL_474154

Residue:

376

Sequence:

MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT
ICDLARTFAREMGEAN

BDBM50132291

n/a

Name

BDBM50132291

Synonyms:

1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | 1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | 1-((2R,3S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | 1-(beta-D-arabinofuranosyl)thymine | 1-beta-D-arabinofuranosylthymine | CHEMBL103283

Type

Small organic molecule

Emp. Form.

C10H14N2O6

Mol. Mass.

258.228

SMILES

Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)[nH]c1=O |r|

Structure