| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase 2, mitochondrial |
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| Ligand | BDBM50206495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454745 (CHEMBL886767) |
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| IC50 | 44000±n/a nM |
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| Citation |  Ciliberti, N; Manfredini, S; Angusti, A; Durini, E; Solaroli, N; Vertuani, S; Buzzoni, L; Bonache, MC; Ben-Shalom, E; Karlsson, A; Saada, A; Balzarini, J Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem15:3065-81 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase 2, mitochondrial |
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| Name: | Thymidine kinase 2, mitochondrial |
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| Synonyms: | KITM_HUMAN | TK2 | Thymidine kinase, mitochondrial |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31013.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1333885 |
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| Residue: | 265 |
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| Sequence: | MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP
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| BDBM50206495 |
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| n/a |
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| Name | BDBM50206495 |
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| Synonyms: | 1-[2'-O-(4-methoxyphenylacetyl)-beta-D-arabinofuranosyl]-5(E)-(2-bromovinyl)uracil | CHEMBL241408 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21BrN2O8 |
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| Mol. Mass. | 497.293 |
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| SMILES | COc1ccc(CC(=O)O[C@H]2[C@H](O)[C@@H](CO)O[C@H]2n2cc(C=CBr)c(=O)[nH]c2=O)cc1 |w:22.23| |
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| Structure | 
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