| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
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| Ligand | BDBM50218044 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457003 (CHEMBL923346) |
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| Ki | 812±n/a nM |
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| Citation |  Kumar, N; Kaur, K; Aeron, S; Dharmarajan, S; Silamkoti, AD; Mehta, A; Gupta, S; Chugh, A; Gupta, JB; Salman, M; Palle, VP; Cliffe, IA Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists. Bioorg Med Chem Lett17:5256-60 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M2 |
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| Name: | Muscarinic acetylcholine receptor M2 |
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| Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51555.53 |
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| Organism: | RAT |
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| Description: | P10980 |
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| Residue: | 466 |
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| Sequence: | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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| BDBM50218044 |
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| n/a |
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| Name | BDBM50218044 |
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| Synonyms: | (R)-N-((1S,5R,6s)-3-(3,4-dimethylphenethyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide | CHEMBL401154 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36N2O2 |
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| Mol. Mass. | 432.5976 |
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| SMILES | Cc1ccc(CCN2C[C@H]3[C@@H](C2)[C@@H]3NC(=O)C(O)(C2CCCC2)c2ccccc2)cc1C |w:16.18| |
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| Structure | 
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