| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50227670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_459972 (CHEMBL943100) |
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| EC50 | 1110±n/a nM |
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| Citation |  Matthews, JM; Chen, X; Cryan, E; Hlasta, DJ; Rybczynski, PJ; Strauss, K; Tang, Y; Xu, JZ; Yang, M; Zhou, L; Demarest, KT Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. Bioorg Med Chem Lett17:6773-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_RAT | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52374.28 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_834194 |
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| Residue: | 468 |
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| Sequence: | MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSC
PGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFV
IHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDT
FLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
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| BDBM50227670 |
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| n/a |
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| Name | BDBM50227670 |
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| Synonyms: | (S)-2-methyl-2-(2-(3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)propanoic acid | CHEMBL250888 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F3N2O4S |
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| Mol. Mass. | 454.463 |
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| SMILES | CC(C)(Sc1ccc2C[C@@H](Cc2c1)NC(=O)Nc1ccc(OC(F)(F)F)cc1)C(O)=O |
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| Structure | 
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