| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50233472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463817 (CHEMBL948896) |
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| IC50 | 238±n/a nM |
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| Citation |  Whitlock, GA; Blagg, J; Fish, PV 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity. Bioorg Med Chem Lett18:596-9 (2008) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 70322.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31645 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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| BDBM50233472 |
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| n/a |
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| Name | BDBM50233472 |
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| Synonyms: | (2-(3-chlorophenoxy)phenyl)-N,N-dimethylmethanamine | CHEMBL257424 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16ClNO |
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| Mol. Mass. | 261.747 |
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| SMILES | CN(C)Cc1ccccc1Oc1cccc(Cl)c1 |
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| Structure | 
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