| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
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| Ligand | BDBM50371825 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_464100 (CHEMBL948141) |
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| IC50 | 3776±n/a nM |
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| Citation |  Shao, L; Hewitt, M; Jerussi, TP; Wu, F; Malcolm, S; Grover, P; Fang, K; Koch, P; Senanayake, C; Bhongle, N; Ribe, S; Bakale, R; Currie, M In vitro and in vivo evaluation of O-alkyl derivatives of tramadol. Bioorg Med Chem Lett18:1674-80 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent noradrenaline transporter |
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| Name: | Sodium-dependent noradrenaline transporter |
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| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69337.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23975 |
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| Residue: | 617 |
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| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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| BDBM50371825 |
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| n/a |
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| Name | BDBM50371825 |
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| Synonyms: | CHEMBL404197 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H31NO2 |
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| Mol. Mass. | 317.4656 |
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| SMILES | COc1cccc(c1)[C@]1(CCCC[C@@H]1CN(C)C)OCC1CC1 |
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| Structure | 
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