| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nitric oxide synthase, inducible |
|---|
| Ligand | BDBM50372210 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_464818 (CHEMBL946889) |
|---|
| IC50 | 160±n/a nM |
|---|
| Citation |  Le Bourdonnec, B; Leister, LK; Ajello, CA; Cassel, JA; Seida, PR; O'Hare, H; Gu, M; Chu, GH; Tuthill, PA; DeHaven, RN; Dolle, RE Discovery of a series of aminopiperidines as novel iNOS inhibitors. Bioorg Med Chem Lett18:336-43 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nitric oxide synthase, inducible |
|---|
| Name: | Nitric oxide synthase, inducible |
|---|
| Synonyms: | HEP-NOS | Hepatocyte NOS | Inducible NO synthase | Inducible NOS | NOS type II | NOS2 | NOS2A | NOS2_HUMAN | Nitric oxide synthase, inducible (iNOS) | iNOS |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 131141.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35228 |
|---|
| Residue: | 1153 |
|---|
| Sequence: | MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL
|
|
|
|---|
| BDBM50372210 |
|---|
| n/a |
|---|
| Name | BDBM50372210 |
|---|
| Synonyms: | CHEMBL256618 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H22ClN3 |
|---|
| Mol. Mass. | 303.83 |
|---|
| SMILES | Clc1ccc(C#N)c(CN(CC2CC2)C2CCNCC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
