Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM50374450 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_469339 (CHEMBL932893) |
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Ki | 27±n/a nM |
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Citation | Bergman, JM; Roecker, AJ; Mercer, SP; Bednar, RA; Reiss, DR; Ransom, RW; Meacham Harrell, C; Pettibone, DJ; Lemaire, W; Murphy, KL; Li, C; Prueksaritanont, T; Winrow, CJ; Renger, JJ; Koblan, KS; Hartman, GD; Coleman, PJ Proline bis-amides as potent dual orexin receptor antagonists. Bioorg Med Chem Lett18:1425-30 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM50374450 |
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n/a |
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Name | BDBM50374450 |
Synonyms: | CHEMBL404053 |
Type | Small organic molecule |
Emp. Form. | C27H25FN4O2 |
Mol. Mass. | 456.5114 |
SMILES | Fc1ccccc1-c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)CCc1nc2ccccc2[nH]1 |
Structure |
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