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TargetRAF proto-oncogene serine/threonine-protein kinase
LigandBDBM50095395
Substrate/Competitorn/a
Meas. Tech.ChEMBL_470479 (CHEMBL951323)
IC50 18000±n/a nM
Citation Zhu, TJiao, YChen, YDWang, XLi, HFZhang, LYLu, T Pharmacophore identification of Raf-1 kinase inhibitors. Bioorg Med Chem Lett18:2346-50 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase
Name:RAF proto-oncogene serine/threonine-protein kinase
Synonyms:C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:Serine/threonine-protein kinase
Mol. Mass.:73082.52
Organism:Homo sapiens (Human)
Description:P04049
Residue:648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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  Blast E-value cutoff:
BDBM50095395
n/a
NameBDBM50095395
Synonyms:3-[3-(4-Amino-phenyl)-ureido]-5-tert-butyl-thiophene-2-carboxylic acid methyl ester | CHEMBL18942 | methyl 3-(3-(4-aminophenyl)ureido)-5-tert-butylthiophene-2-carboxylate
TypeSmall organic molecule
Emp. Form.C17H21N3O3S
Mol. Mass.347.432
SMILESCOC(=O)c1sc(cc1NC(=O)Nc1ccc(N)cc1)C(C)(C)C
Structure
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