| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin S |
|---|
| Ligand | BDBM50376510 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_477023 (CHEMBL933741) |
|---|
| IC50 | 460±n/a nM |
|---|
| Citation |  Teno, N; Irie, O; Miyake, T; Gohda, K; Horiuchi, M; Tada, S; Nonomura, K; Kometani, M; Iwasaki, G; Betschart, C New chemotypes for cathepsin K inhibitors. Bioorg Med Chem Lett18:2599-603 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin S |
|---|
| Name: | Cathepsin S |
|---|
| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37507.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25774 |
|---|
| Residue: | 331 |
|---|
| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
|
|
|
|---|
| BDBM50376510 |
|---|
| n/a |
|---|
| Name | BDBM50376510 |
|---|
| Synonyms: | CHEMBL261673 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19N5O |
|---|
| Mol. Mass. | 321.3764 |
|---|
| SMILES | CC(C)(C)CNc1nc(ncc1C#CCOc1cccnc1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
