| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
|---|
| Ligand | BDBM50377913 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_486934 (CHEMBL1012196) |
|---|
| Ki | 27±n/a nM |
|---|
| Citation |  Verotta, L; Appendino, G; Belloro, E; Bianchi, F; Sterner, O; Lovati, M; Bombardelli, E Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety. J Nat Prod65:433-8 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor subfamily 1 group I member 2 |
|---|
| Name: | Nuclear receptor subfamily 1 group I member 2 |
|---|
| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
|---|
| Type: | Nuclear receptor |
|---|
| Mol. Mass.: | 49774.77 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75469 |
|---|
| Residue: | 434 |
|---|
| Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
|
|
|
|---|
| BDBM50377913 |
|---|
| n/a |
|---|
| Name | BDBM50377913 |
|---|
| Synonyms: | HYPERFORIN |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H52O4 |
|---|
| Mol. Mass. | 536.785 |
|---|
| SMILES | [#6]-[#6](-[#6])-[#6](=O)[C@@]12[#6](=O)-[#6](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](=O)[C@@]([#6]\[#6]=[#6](\[#6])-[#6])([#6]-[#6@H](-[#6]\[#6]=[#6](\[#6])-[#6])[C@@]1([#6])[#6]-[#6]\[#6]=[#6](\[#6])-[#6])[#6]2=O |r,TLB:38:37:14.6.8:22.29.23| |
|---|
| Structure | 
|
|---|
Search and Browse
