| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50042949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_510416 (CHEMBL1003092) |
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| Kd | 100000±n/a nM |
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| Citation |  Rothweiler, U; Czarna, A; Weber, L; Popowicz, GM; Brongel, K; Kowalska, K; Orth, M; Stemmann, O; Holak, TA NMR screening for lead compounds using tryptophan-mutated proteins. J Med Chem51:5035-42 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50042949 |
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| n/a |
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| Name | BDBM50042949 |
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| Synonyms: | (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one (21) | (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one | (E)-3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phenyl)-propenone | 3,4,2',4'-tetrahydroxychalone | 3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phenyl)-propenone | Butein | CHEMBL128000 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12O5 |
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| Mol. Mass. | 272.2528 |
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| SMILES | Oc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(O)c1 |
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| Structure | 
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