Reaction Details | |||
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Target | Sigma non-opioid intracellular receptor 1 | ||
Ligand | BDBM50275323 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_496151 (CHEMBL1000140) | ||
Ki | 2.9±n/a nM | ||
Citation | Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem51:7523-31 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sigma non-opioid intracellular receptor 1 | |||
Name: | Sigma non-opioid intracellular receptor 1 | ||
Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein | ||
Type: | Protein | ||
Mol. Mass.: | 25307.17 | ||
Organism: | Cavia porcellus (Guinea pig) | ||
Description: | Q60492 | ||
Residue: | 223 | ||
Sequence: |
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BDBM50275323 | |||
n/a | |||
Name | BDBM50275323 | ||
Synonyms: | CHEMBL486136 | trans-1-(4-(2-methoxyphenyl)cyclohexyl)-4-(pyridin-2-yl)piperazine | ||
Type | Small organic molecule | ||
Emp. Form. | C22H29N3O | ||
Mol. Mass. | 351.4852 | ||
SMILES | COc1ccccc1[C@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:8.8,wD:11.15,(-11.09,-34.13,;-12.43,-34.91,;-12.42,-36.44,;-13.75,-37.21,;-13.75,-38.76,;-12.42,-39.53,;-11.07,-38.76,;-11.08,-37.21,;-9.75,-36.43,;-9.76,-34.89,;-8.42,-34.12,;-7.09,-34.89,;-7.09,-36.43,;-8.41,-37.19,;-5.76,-34.12,;-4.43,-34.89,;-3.1,-34.13,;-3.09,-32.59,;-4.42,-31.82,;-5.76,-32.58,;-1.76,-31.83,;-1.76,-30.29,;-.43,-29.53,;.91,-30.3,;.9,-31.84,;-.43,-32.6,)| | ||
Structure |