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TargetHistone acetyltransferase KAT2B
LigandBDBM50255524
Substrate/Competitorn/a
Meas. Tech.ChEMBL_515394 (CHEMBL1025549)
IC50 65930±n/a nM
Citation Wu, JXie, NWu, ZZhang, YZheng, YG Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60. Bioorg Med Chem17:1381-6 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone acetyltransferase KAT2B
Name:Histone acetyltransferase KAT2B
Synonyms:Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF
Type:PROTEIN
Mol. Mass.:93045.76
Organism:Homo sapiens (Human)
Description:ChEMBL_1502838
Residue:832
Sequence:
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50255524
n/a
NameBDBM50255524
Synonyms:Ac-SGRGK(CoA)GGKGLGKGGAKRHRK | CHEMBL505605
TypeSmall organic molecule
Emp. Form.C107H188N43O40P3S
Mol. Mass.2841.888
SMILESCC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CO)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(O)=O |r,wU:139.142,65.64,67.76,29.88,108.113,153.155,93.103,174.177,wD:68.68,70.71,49.49,144.146,12.17,164.166,4.4,185.188,122.124,(32.95,-10.85,;32.95,-9.29,;34.26,-8.53,;31.63,-8.53,;31.63,-6.98,;30.31,-6.18,;28.99,-6.97,;28.99,-8.52,;27.64,-6.19,;26.3,-6.95,;24.94,-6.21,;24.94,-4.69,;23.63,-6.97,;23.63,-8.52,;24.94,-9.28,;24.94,-10.84,;26.26,-11.59,;26.25,-13.1,;22.32,-6.16,;21.02,-6.99,;21.02,-8.55,;19.66,-6.21,;18.3,-6.93,;16.95,-6.2,;16.95,-4.67,;15.63,-6.95,;14.32,-6.15,;13.03,-6.99,;13.03,-8.54,;11.68,-6.2,;11.68,-4.69,;13.03,-3.91,;13.03,-2.39,;14.37,-1.62,;14.37,-.08,;15.75,.61,;17.08,-.16,;15.75,2.15,;17.08,2.92,;18.42,3.69,;18.42,5.23,;19.76,6.01,;21.09,5.23,;21.09,3.69,;22.42,6.01,;23.77,5.23,;25.1,6.01,;25.1,7.55,;23.77,8.33,;26.43,8.33,;26.43,9.86,;27.77,7.55,;29.11,6.77,;28.54,8.89,;27,6.21,;27.77,4.88,;27,3.53,;26.23,2.2,;25.66,4.31,;28.33,2.77,;28.33,1.22,;28.33,-.32,;26.79,1.22,;29.88,1.22,;30.64,2.56,;32.19,2.56,;33.1,3.81,;34.56,3.33,;34.56,1.79,;35.81,.88,;33.1,1.32,;32.62,-.15,;33.65,-1.29,;34.68,-2.44,;32.5,-2.33,;34.8,-.26,;35.81,4.24,;35.81,5.78,;37.28,6.26,;38.18,5.01,;39.71,4.85,;40.62,6.1,;40.34,3.44,;39.44,2.19,;37.9,2.36,;37.28,3.76,;10.29,-6.87,;8.9,-6.2,;8.9,-4.68,;7.58,-6.96,;6.26,-6.17,;4.94,-6.96,;4.94,-8.51,;3.59,-6.18,;3.59,-4.66,;4.94,-3.88,;4.94,-2.37,;6.27,-1.6,;6.25,-.06,;4.94,.8,;7.61,.79,;2.23,-6.9,;.86,-6.19,;.86,-4.67,;-.47,-6.95,;-1.76,-6.12,;-3.06,-6.95,;-3.06,-8.48,;-4.39,-6.18,;-4.39,-4.63,;-3.02,-3.68,;-5.77,-6.86,;-7.14,-6.17,;-8.48,-6.94,;-7.14,-4.63,;32.95,-6.22,;32.95,-4.7,;34.29,-6.96,;35.63,-6.2,;36.98,-6.97,;36.98,-8.53,;38.31,-6.2,;39.64,-6.98,;39.64,-8.53,;40.96,-9.29,;40.96,-10.85,;42.28,-11.6,;42.22,-13.16,;40.96,-6.22,;40.96,-4.7,;42.28,-7.02,;43.62,-6.26,;44.97,-7.04,;44.97,-8.6,;46.31,-6.28,;47.68,-6.98,;49,-6.22,;49,-4.71,;50.29,-7.06,;51.61,-6.28,;51.61,-4.76,;52.96,-7.05,;52.96,-8.61,;54.3,-6.29,;55.68,-6.98,;55.68,-8.54,;56.99,-9.3,;56.99,-10.85,;58.31,-11.61,;58.23,-13.21,;56.99,-6.22,;56.99,-4.7,;58.31,-7.03,;59.63,-6.25,;59.63,-4.74,;60.98,-3.96,;60.98,-2.44,;62.33,-1.68,;62.38,-.14,;61.02,.57,;63.66,.6,;60.98,-7.03,;60.98,-8.58,;62.32,-6.27,;63.68,-6.98,;63.68,-8.54,;65,-9.3,;66.39,-8.7,;67.42,-9.86,;66.64,-11.18,;65.14,-10.84,;65,-6.23,;65,-4.72,;66.33,-7.01,;67.66,-6.23,;67.66,-4.71,;69.01,-3.93,;69.01,-2.41,;70.36,-1.67,;70.36,-.13,;69.05,.59,;71.7,.62,;69.01,-7,;69.01,-8.55,;70.35,-6.24,;71.69,-7,;71.69,-8.56,;73,-9.32,;73,-10.88,;74.32,-11.64,;74.33,-13.2,;73,-6.25,;74.35,-7.03,;73,-4.73,)|
Structure
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