| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heat shock protein HSP 90-beta |
|---|
| Ligand | BDBM20758 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_543926 (CHEMBL1020361) |
|---|
| IC50 | 180±n/a nM |
|---|
| Citation |  Taldone, T; Sun, W; Chiosis, G Discovery and development of heat shock protein 90 inhibitors. Bioorg Med Chem17:2225-35 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heat shock protein HSP 90-beta |
|---|
| Name: | Heat shock protein HSP 90-beta |
|---|
| Synonyms: | HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) |
|---|
| Type: | Molecular Chaperone |
|---|
| Mol. Mass.: | 83229.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08238 |
|---|
| Residue: | 724 |
|---|
| Sequence: | MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
|
|
|
|---|
| BDBM20758 |
|---|
| n/a |
|---|
| Name | BDBM20758 |
|---|
| Synonyms: | 9-butyl-8-[(7-chloro-1,3-benzothiazol-2-yl)sulfanyl]-9H-purin-6-amine | Benzothiazole analogue, 11 | CHEMBL213262 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15ClN6S2 |
|---|
| Mol. Mass. | 390.914 |
|---|
| SMILES | CCCCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc12 |
|---|
| Structure | 
|
|---|
Search and Browse
