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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50249105 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_499971 (CHEMBL1019341) | ||
| EC50 | >5000±n/a nM | ||
| Citation |  Yang, BV; Vaccaro, W; Doweyko, AM; Doweyko, LM; Huynh, T; Tortolani, D; Nadler, SG; McKay, L; Somerville, J; Holloway, DA; Habte, S; Weinstein, DS; Barrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
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| BDBM50249105 | |||
| n/a | |||
| Name | BDBM50249105 | ||
| Synonyms: | CHEMBL514185 | N-(2-hydroxy-4-nitrophenyl)-15-methyltetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | TCMDC-124076 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H20N2O4 | ||
| Mol. Mass. | 400.4266 | ||
| SMILES | CC1(CC2c3ccccc3C1c1ccccc21)C(=O)Nc1ccc(cc1O)[N+]([O-])=O |TLB:0:1:4.9:11.16,8:9:2.1:11.16,12:11:4.9:2.1,THB:17:1:4.9:11.16,(21.57,-.39,;22.91,-1.16,;23.42,-1.93,;23.43,-4.12,;21.56,-4.64,;20.22,-5.41,;18.88,-4.64,;18.89,-3.09,;20.21,-2.32,;21.52,-3.24,;22.91,-2.58,;24.45,-3.47,;25.72,-2.73,;27,-3.46,;27,-4.95,;25.72,-5.69,;24.44,-4.95,;23.67,.18,;22.88,1.51,;25.21,.2,;25.97,1.54,;25.19,2.86,;25.94,4.2,;27.49,4.22,;28.27,2.89,;27.52,1.55,;28.3,.22,;28.23,5.57,;29.78,5.59,;27.45,6.9,)| | ||
| Structure | 
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